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KMID : 0928520100200020263
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Korean Journal of Lipidology
2010 Volume.20 No. 2 p.263 ~ p.271
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Relation between Changes in C-reactive Protein and Low Density Lipoprotein
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Cho Eun-Jung
Min Yun-joo
Oh Min-Seok
Kwon Jee-Eun
Kim Jung-Eun
Lee Wang-Soo
Lee Kwang-Je
Kim Sang-Wook
Kim Tae-Ho
Kim Chee-Jeong
Ryu Wang-Seong
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Abstract
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Background/Aims : Statin decreases C-reactive protein (CRP) levels. However, it is unclear whether this effect is mediated by direct effect or secondary to low density lipoprotein-cholesterol (LDL-C) lowering. We evaluated the relation between changes in CRP and cholesterol levels in hypercholesterolemic patients treated with statins with different potencies.
Methods: Hypercholesterolemic patients were divided into two groups, the atorvastatin group (n=77) and the lovastatin group (n=66). Lipid and CRP levels were measured before and after 2 months of therapy.
Results: Atorvastatin lowered LDL-C levels (41.5%, P<0.001) more than lovastatin (31.5%, P<0.001) (P<0.001). CRP levels decreased in the atorvastatin group (from 1.67±0.36 to 1.18±1.16 mg/L, P=0.007) and in the lovastatin group (from 1.68±0.45 mg/L to 1.34±0.39 mg/L, P=0.096) with borderline significance. Changes in CRP levels were not different between the two groups (P=0.14). Changes in CRP levels were not related to those in LDL-C (r=0.08, P=0.34) and cholesterol (r=0.01, P=0.90) at all and were only related to baseline CRP levels (r=0.67, P<0.001).
Conclusions:Changes in CRP levels were not related to changes in total and LDL-C levels. This finding suggests that CRP lowering effect of statin is not secondary to cholesterol lowering effect but the direct effect of the drug.
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KEYWORD
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C-reactive protein, Statin, Low density lipoprotein-cholesterol, Lipids
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